# Our published work.

Papers, preprints, and manuscripts from the Verge Labs team. Verge co-authors in **bold**.

## Reports

[**Introducing vBx-1.0**](https://vergelabs.com/resources/reports/vbx-one-technical-report/)  
Verge’s multi-modal foundation model for precision neurology  
By Verge Labs  
Published: June 16, 2026

## Publications

| Year | Title / Venue / Authors | Program | Status |
|------|-------------------------|---------|--------|
| 2026 | [Glycoprotein Non-Metastatic Melanoma Protein B (GPNMB): A Translational Pharmacodynamic Biomarker for PIKfyve Inhibition With VRG50635](https://ascpt.onlinelibrary.wiley.com/doi/10.1111/cts.70489)  
Clinical and Translational Science · DOI 10.1111/cts.70489  
**Gontier** G, **Kim** G, **Wang** C, **Zhu** K, **Gau** R, **Zhang** N, **Naphade** S, **Stewart** A, **Schmidt** MJ, **Galemmo** R, **Shook** B, **Tarachandani** A, **Choi** I, **Raines** S, **Scannevin** RH, Grievink HW, Smits LMG, Kremer PHC, **Cadavid** D | ALS / VRG50635 | Published |
| 2025 | Proof-of-concept study of the PIKfyve inhibitor VRG50635 in familial and sporadic ALS (Phase 1b)  
Annals of Neurology (submitted Dec 2025)  
**Cadavid** D, et al. (Verge VRG50635 team) | ALS / VRG50635 | In Submission |
| 2025 | CD38 inhibition reduces inflammatory response and alters metabolism of activated primary human T cells  
Frontiers in Immunology (submitted Oct 2025)  
**Heinrich** L, **Choi** I, **Scannevin** RH, **Dhara** M | Obesity / VRG201 | In Submission |
| 2024 | [Unravelling cell type-specific responses to Parkinson’s Disease at single cell resolution](https://molecularneurodegeneration.biomedcentral.com/articles/10.1186/s13024-023-00699-0)  
Molecular Neurodegeneration · DOI 10.1186/s13024-023-00699-0  
Martirosyan A, Ansari R, Pestana F, **Hebestreit** K, Ghosh H, Poovathingal S, Hadzhiev Y, Hadziahmetovic A, **Cisterna** A, Hardy J, **Mighdoll** M, **Scannevin** R, **Kottick** A, **Hanson-Smith** V, **Guelfi** S, et al. | Parkinson’s Disease | Published |
| 2022 | [Single-nucleus co-expression networks of dopaminergic neurons support iron accumulation as a plausible explanation to their vulnerability in Parkinson’s disease](https://www.biorxiv.org/content/10.1101/2022.12.13.514863v1)  
bioRxiv (preprint) · DOI 10.1101/2022.12.13.514863  
Gómez-Pascual A, Martirosyan A, **Hebestreit** K, Mameffe C, Poovathingal S, **Belgard** TG, **Altar** CA, **Kottick** A, **Holt** M, **Hanson-Smith** V, **Cisterna** A, **Mighdoll** M, **Scannevin** R, **Guelfi** S | Parkinson’s Disease | Preprint |
| 2022 | [Systematic comparative analysis of strand-specific RNA-seq library preparation methods for low input samples](https://doi.org/10.1038/s41598-021-04583-z)  
Scientific Reports (Nature Portfolio) · DOI 10.1038/s41598-021-04583-z  
**Naphade** S, **Bhatnagar** R, **Hanson-Smith** V, **Choi** I, **Zhang** A | CONVERGE Platform | Published |
| 2020 | [A framework for integrating directed and undirected annotations to build explanatory models of cis-eQTL data](https://journals.plos.org/ploscompbiol/article?id=10.1371%2Fjournal.pcbi.1007770)  
PLOS Computational Biology · DOI 10.1371/journal.pcbi.1007770  
**Lamparter** D, **Bhatnagar** R, **Hebestreit** K, **Belgard** TG, **Zhang** A, **Hanson-Smith** V | CONVERGE Platform | Published |
| 2018 | [Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons](https://www.nature.com/articles/nm.4490)  
Nature Medicine · DOI 10.1038/nm.4490  
Shi Y, Lin S, Staats KA, ..., **Chen** JA, **Hanson-Smith** V, **Belgard** TG, **Zhang** A, et al. | ALS / C9ORF72 | Published |